In 2007, between 40.000 and 50,000 people in the United States will be diagnosed with primary brain tumors, the majority of whom will be adults. Three times this number will develop metastatic brain tumors from cancer originating elsewhere in the body. This issue of Neurologic Clinics contains the following articles: Epidemiology of Brain Tumors (Wrensch, Claus); Molecular Pathogenesis of Brain Tumors and the Role of Stem Cells (Ligon, Kesari); Advances in Neuroimaging of Brain Tumors (Henson); Medical Management of Brain Tumor Patients (Schiff, Wen); Advances in Neurosurgery for Brain Tumors (Shaffrey); Advances in Radiation Therapy for Brain Tumors (Mehta); Novel Therapies for Brain Tumors (Wen, Schiff); Anaplastic Astrocytomas and Glioblastomas (Reardon); Anaplastic Oligodendrogliomas and Anaplastic Oligoastrocytomas (Van Den Bent); Low-Grade Gliomas (Lang, Gilbert); Brain Metastases (Deangelis); Benign Brain Tumors (Link); Primary CNS Lymphoma (Abrey); and Genetic Causes of Brain Tumors (Plotkin).